The high increase in the temperature in the malignant cell tissue attacks the tissue in numerous ways. As is generally known, cell tissue shows super-increased metabolic activity (for faster cell division); however, the provision for this through the tumour's own capillaries is poor. This contradiction has fatal consequences for the tumour cells where the area is overheated, particularly if it occurs suddenly. Firstly, the cell-damaging heat cannot be conducted away from the location, and only to a limited degree [1, 2].

Secondly, the increase in temperature causes a lack of oxygen and nutrients in this tissue. Both of these factors undermine the tumour's conditions for life [3].  This undersupply then inhibits the metabolic processes and consequently the division of the degenerate cells [4].  

The components are damaged by the heat and cannot be sufficiently repaired. These conditions predispose the cells to dying off [5]. In addition, it has been scientifically proven that a temporary concentration of the body's own defense cells in the capillaries can be found in tissue subject to thermotherapy[6] !  

This precarious arrangement becomes even more disadvantageous for the cancer if the thermotherapy is combined with  buserelin therapy(gonadotropin releasing hormone agonist [GnRH]) [25]. It has been demonstrated that an association of this nature multiplies the effectiveness of both components.  

The appropriate use of equipment and depth of penetration of the heat permits the use of local thermotherapy in a wide range of cancer cases, e.g. cancer of the breast [7, 8],, abdomen (gynecological cancers) [9],  and prostate [10, 11], in tumours in the stomach [12] , intestine [13],  lungs  [14, 24],      liver [15]  and pancreas[16, 26] , in cancer in the area of the throat, nose and ears  [17, 18], as well as in brain tumours [19]   , cancer of the lymph nodes [20]  and metastases of the different types of cancer [21, 22]..

Experience has shown that local deep thermotherapy, especially before and after surgical removal of tumorous tissue aids the recovery process and counteracts later occurrences of metastases [23].  

The frequency and duration of application of thermotherapy depends entirely on the individual disease profile. This therapy is generally extremely well tolerated. No significant side-effects occur, even in combination with other treatments.

The heat is in any event restricted, and is only applied directly on the tissue or organ affected by the tumour. The patient is placed on a water bed during treatment. The heating process takes place using electromagnetic waves for approximately 60 minutes at the intended temperature. The process is regulated by means of control electronics and is subject to permanent control to prevent the occurrence of heat damage [23].
All types of cancer can be subjected to therapy of this nature, except in persons with pacemakers. Certain application modifications are made for patients with metal implants in their movement apparatus or thoracic cage. Metal fillings in the teeth are however completely harmless.

References

1.Andocs G, Renner H, Balogh L, Fonyad L, Jakab C, Szasz A. Strong synergy of heat and modulated electromagnetic field in tumor cell killing.Radiology and Oncology.  2009;185(2):120–126.  [PubMed]

2. Hegyi G, Szigeti GP, Szász A.  Hyperthermia versus  Oncothermia: Cellular Effects in Complementary Cancer Therapy.Evid Based Complement Alternat Med. 2013;2013:672873.

3. Hegyi G, Szasz O, Szasz A.  Oncothermia: a new paradigm and promising method in cancer therapies.  Acupunct Electrother Res. 2013;38(3-4):161-97.

4. Hegyi G, Szigeti GP, Szász A.  Hyperthermia versus  Oncothermia: Cellular Effects in Complementary Cancer Therapy.Evid Based Complement Alternat Med. 2013;2013:672873.

5. Andocs G, Szasz O, Szasz A.  Oncothermia  treatment of cancer: from the laboratory to clinic.  Electromagn Biol Med. 2009;28(2):148-65.

6.  Fiorentini G1,  Szasz A. Hyperthermia today: electric energy, a new opportunity in  cancer  treatment.  J  Cancer  Res Ther.  2006 Apr-Jun;2(2):41-6.

7. Yamamoto C, Yamamoto D, Tsubota Y, Sueoka N, Kawakami K, Yamamoto M.  The synergistic effect of  local  microwave  hyperthermia  and chemotherapy for advanced or recurrent  breast cancer].Gan To Kagaku Ryoho.  2014 Nov;41(12):1921-3

8.  Juckstock J, Eberhardt B, Sommer HL (2011) Locoregional hyperthermia in combination with chemotherapy for metastatic breast cancer patients: The Mammatherm – trial. Oncothermia Journal 2:51-55

9.    Woong J, Seung CK (2011) Oncothermia in Gynecologic Oncology. Oncothermia Journal 3:71-71

10.  Müller M (2010) Warum ich Prostatahyperthermie mache – Datenlage. Oncothermia Journal 1:16-16  

11.  Kleef R (2013) Application of transurethral prostate hyperthermia in benign and malign prostate hyperplasia and chronic prostatitis. Oncothermia Journal 7:71-71

12.  Tae SJ, Sun YM, Jeasang Y, Sangwook L (2013) Cases that respond to Oncothermia monotherapy. Oncothermia Journal 7:267-277

13.  Pang LKC (2012) Clinical Research on Integrative Treatment of Colon Carcinoma with Oncothermia and Clifford TCM Immune Booster. Oncothermia Journal 5:24-41,

14. Dani A, Varkonyi A, Magyar T, Szasz A (2011) Clinical study for advanced non-small-cell lung cancer treated by oncothermia. Oncothermia Journal 3:40-49 ,

15  Hager ED, Dziambor H, Hohmann D, Gallenbeck D, Stephan M, Popa C,  et al  . Deep hyperthermia with radiofrequencies in patients with liver metastases from colorectal cancer. Anticancer Res 1999;19:3403-8.  

16.   Hager ED, Süβe B, Popa C, Schrittwieser G, Heise A, Kleef R. Complex therapy of the not in sano respectable carcinoma of the pancreas - a pilot study. J Can Res Clin Oncol 1994;120:R47.,  

17.  Vokalis I, Kouridakis P, Daniilidis L, Natsouki V, Kalyvas S, Maragkos M, Dimitriadis K (2013) Loco regional hyperthermia in Greece: A new treatment modality for treating deep seated tumors. Two years clinical experience from Thessaloniki hyperthermia’s – Oncology operation center – New challegnes. Oncothermia Journal 7:381-381

18.  Nagraj Huilgol, Sapna Gupta-Dutta, CR Sridhar (2014) Hyperthermia in the management of head and neck cancer – A single institution study from India. Oncothermia Journal 10:64-67

19.  Andras Szasz (2014) Deep Hyperthermia in Oncology. Oncothermia Journal 10:32-32

20.  Szasz A, Szasz O (2014) Case reports made with Oncothermia I. Oncothermia Journal 11:9-70

21.    Lorencz P, Csejtei A (2013) Experience in the treatment of liver metastases with special reference to the consequences of interruption of long-run treatments. Oncothermia Journal 7:293-294

22.  Coletta D, Gargano L, Assogna M, Castigliani G, De Chicchis M, Gabrielli F, Mauro F, Pantaleoni G, Pigliucci GM (2013) Stabilization of metastatic breast cancer with capacitive hyperthermia plus standard-dose chemotherapy and/or metronomic. Oncothermia Journal 7:302-304

23.  Szasz A, Szasz O (2013) Oncothermia protocol. Oncothermia Journal 8:13-45

24.  Szasz A1. Current status of  oncothermia  therapy for lung cancer.  Korean J Thorac Cardiovasc Surg.  2014 Apr;47(2):77-93. doi: 10.5090/kjtcs.2014.47.2.77. Epub 2014 Apr 10.

25. Koutsilieris M, Faure N, Tolis G, Laroche B, Robert G, Ackman CF.  Objective  response  and  disease  outcome  in  59  patients  with  stageD2  prostatic cancer  treated  with either  Buserelin  or  orchiectomy.Disease  aggressivity  and its  association  with  response  andoutcome.  Urology.  1986  Mar;27(3):221-8.

26. Dani A, Varkonyi A, Magyar T, Kalden M, Szasz A (2012) Clinical study for advanced pancreas cancer treated by oncothermia. Oncothermia Journal 6:11-25